With spyware/malware issues on your computer, it isn't necessarily how often you run the scans, it is sometimes where you have been that leads to all sorts of problems, but with 'automatic' anything on your computer, this means, without you actually starting the task yourself, you are unaware if everything is going to work as it is supposed to. So in software programs you will have indicators and prompts stating the obvious "you are out of date and should update" with a button you press to start the update. Depending on the software, it will then either automatically install, or allow you to complete the process. Again, depending on the automatic settings built in to the program. The most recent release of Ad Aware takes advantage of a 'service' which is basically a program that runs in the background that will monitor such things as updates that are available and automatically download and install to your computer. This means it is always listening to the internet and catches only what it is supposed to. But if this should get 'hacked' by some other malicious software script, then it could do more damage then good. Therefore when you do start Ad Aware and choose to update, you may get an error but that may also be because the website (server) is busy with too many other people also getting updates or simply automatically updating. Remember this is a free service with the ability to purchase the professional version and if you do, this 'service' that is running on your computer, you actually are paying for in more ways then one! So is it safer to have this service running and protecting, essentially slowing down your computer, all-be-it a small amount, but this could become a source of problems, should attempts to update be blocked and when you get errors, once or twice, (I typically suggest noting the time of day you are performing the update as it may reflect to busier times of updating?? you never know... but it could also some form of malware attempting to hide itself on your system by eliminating or blocking a service that is supposed to be running either 'all the time' or when prompted in the case of the updating of definitions.
In short, what should you do if you get an error when trying to update Ad Aware. Click cancel and, if you still want to perform a scan, continue on, but note you are doing a scan on older definitions, not that it can't help, but then that will be determined on just how old the definitions are and how long it has been since the last scan. Try again later, but if it persists (which I would say is for over a week or 7-10 times of attempting to update at various times of the day. Since this is not the only line of defense, it should not necessarily be a very high priority in the maintenance and cleaning and optimizing of your computer, but should be a simple note to watch. And, if you are an existing client of mine, you would be probably emailing me with the comments that it has been about a week without success, as this, in my opinion, would deem the need to have your computer checked over/scanned by a technician or someone that knows what to look for when it comes to malware and other nasties.
Since Ad Aware is only one of a number of anti-spyware programs I recommend running on a daily basis, it is good to keep track of this sort of maintenance unless you are paying for someone to do it for you and this is something more and more people are finding they are doing as they use their computer more and more as a tool in your every day and every minute of the day lifestyle.